منابع مشابه
Dual-Target Anticancer Drug Candidates: Rational Design and Simulation Studies
This study aims to design some dual-target anticancer candidates, capable to act as an alkylating agent as well as a thymidylate synthase (TS) inhibitor. The designed scaffold is a combination of nucleobase, amino acid and aziridine structures. The candidates are docked into TS and three DNA double strand structures and evaluated based on their binding interaction energies and ligand efficienci...
متن کاملdual-target anticancer drug candidates: rational design and simulation studies
this study aims to design some dual-target anticancer candidates, capable to act as an alkylating agent as well as a thymidylate synthase (ts) inhibitor. the designed scaffold is a combination of nucleobase, amino acid and aziridine structures. the candidates are docked into ts and three dna double strand structures and evaluated based on their binding interaction energies and ligand efficienci...
متن کاملAttentional Control via Parallel Target-Templates in Dual-Target Search
Simultaneous search for two targets has been shown to be slower and less accurate than independent searches for the same two targets. Recent research suggests this 'dual-target cost' may be attributable to a limit in the number of target-templates than can guide search at any one time. The current study investigated this possibility by comparing behavioural responses during single- and dual-tar...
متن کاملDual Formulation of Second Order Target Problems
This paper provides a new formulation of second order stochastic target problems introduced in [19] by modifying the reference probability so as to allow for different scales. This new ingredient enables us to prove a dual formulation of the target problem as the supremum of the solutions of standard backward stochastic differential equations. In particular, in the Markov case, the dual problem...
متن کاملTarget Space Pseudoduality Between Dual Symmetric Spaces
A new set of on shell duality equations is proposed that leads to a map between strings moving on symmetric spaces with opposite curvatures. The transformation maps “waves” on a riemannian symmetric space M to “waves” on its dual riemannian symmetric space M̃ . This transformation preserves the energy momentum tensor though it is not a canonical transformation. The preservation of the energy mom...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2005
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd1672